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Maximum benefit is reached in one to two weeks. The effects last approximately three months thereafter from a single treatment of BOTOX ® Cosmetic. Resulting in the smoothing of your skin and the improvement of fine lines and superficial wrinkles in the area of your treatment. When the effects start wearing off, you will notice a very gradual fading of its effects. At this point you will return for your next treatment. BOTOX ® Cosmetic has proven itself again and again in eliminating superficial lines and wrinkles. Patients report that during a course of treatment their lines seem to disappear and the skin regains its former smoothness.